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Elderly Vic man missing in cold conditions

An elderly Victorian man with short-term memory loss has been missing for more than 24 hours in cold and wet conditions.

Luigi Di Sante, 86, was last seen in St Albans, in Melbourne's northwest, about 12.30pm on Friday. He is thought to be wearing blue jeans, a dark coloured t-shirt and black runners.

The alarm was raised when a nurse came to check on his ill wife on Friday and noticed Mr Di Sante was missing from his home of more than 40 years.

"We're just concerned he is perhaps be seeking shelter somewhere, trying to stay warm or suffering from hypothermia," granddaughter Helen Di Sante told Nine News on Saturday.

"He can remember things from twenty years ago, things in the last hour or so he'll forget," she said of her grandfather.

Also known as Gino, Mr Di Sante is carrying his wallet but speaks little English, his family said.

With conditions in Melbourne set to worsen with wet weather people have been urged to check any areas in their front of backyards where he may seek shelter.

A search will continue through the evening for the missing man and are urging anyone who may have sighted Mr Di Sante to contact police.

The elderly man has a fair complexion, slim build, short white-grey hair and is 170cm.

© AAP 2019